Biology of Human Tumors Extracellular Lumican InhibitsPancreaticCancerCellGrowth and Is Associated with Prolonged Survival after Surgery
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چکیده
Purpose: To evaluate the relevance between lumican expression patterns and the clinical course of patients with pancreatic ductal adenocarcinoma (PDAC), and to investigate the role of lumican in PDAC
منابع مشابه
Lumican expression in advanced colorectal cancer with nodal metastasis correlates with poor prognosis.
Lumican is a member of a small leucine-rich proteoglycan family, and it is reportedly overexpressed in human breast cancer. The expression of lumican in the extracellular matrix in breast cancer is associated with a high tumor grade, low estrogen receptor levels and young age. Lumican expression has been previously reported in colorectal cancer, but the role of lumican in the tumor is not well ...
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PURPOSE Lumican is a keratan sulfate proteoglycan originally identified in cornea, but present in a variety of connective tissues where it presumably regulates collagen fibril formation and organization. The present study was designed to describe the chemical nature of lumican core protein in the aging human sclera. METHODS Western blot analyses, immunohistochemistry, and immunoaffinity chrom...
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تاریخ انتشار 2014